Drug Uses Cymbalta is used for treating depression and generalized anxiety disorder. It is used for managing pain caused by diabetic peripheral neuropathy (DPNP). It may also be used for other conditions as determined by your doctor. How to use Use Cymbalta as directed by your doctor. Check the label on the medicine for exact dosing instructions. Take Cymbalta by mouth with or without food. Swallow Cymbalta whole. Do not break, crush, or chew before swallowing. Do not open the capsule and sprinkle the contents on food or in liquid. Take Cymbalta on a regular schedule to get the most benefit from it. Taking Cymbalta at the same time each day will help you remember to take it. Continue to take Cymbalta even if you feel well. Do not miss any doses. Drug Class and Mechanism Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI). It works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine), which helps to improve certain mood problems. Missed Dose If you miss a dose of Cymbalta, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Cymbalta at 77 degrees F (25 degrees C). Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cymbalta out of the reach of children and away from pets.