Drug Uses ESTRACE is very useful in treating vaginal atrophy and preventing osteoporosis in women and conditions caused by menopause. Usage Following the dosage instructions of your doctor is the best way to use any medication. If you are unsure or do not remember the instructions then you may read the medicine label for more detailed information. You may choose to take ESTRACE with a meal to avoid an upset stomach or without one. ESTRACE works best when taken 30 to 60 minutes before initiating sexual activity. But in some people, it works equally well when taken up to 4 hours before sexual activity. So, it works differently in different people. The dosage should not increase more than once in a day (24 hours). Drug Class and Mechanism ESTRACE falls under sex hormone and used to treat conditions like vaginal atrophy and preventing osteoporosis in women and conditions caused by menopause. Missed Dose Despite your best attempts at remembering, if you still miss out on a dose, then take it as soon as you remember about it. But keep in mind that you will have to adjust your next dose by spacing it out by 4 to 5 hours. If this is not possible, then the best thing to do would be to skip the missed dose and continue with your normal dosage schedule. Never try to compensate for the missed dose by taking a double dose together. It may cause adverse effects. Since it is an erectile dysfunction drug, it must only be used when required. So, there are no chances of a missed dose since it is not taken according to a regular dosage schedule. Storage Store ESTRACE at room temperature(read medicine label if unsure). Always keep it in a cool dark place that is not directly exposed to sources of heat or moisture and sunlight. Protect it from kids and pets. Overdose An overdose of ESTRACE may have adverse effects that require immediate medical attention. Contact the nearest emergency poison control center immediately if you notice effects like excessive vaginal bleeding, severe nausea, and vomiting.