Drug Uses PROMETRIUM is very useful in protecting the lining of the uterus in women on estrogen replacement therapy. Usage Following the dosage instructions of your doctor is the best way to use any medication. If you are unsure or do not remember the instructions then you may read the medicine label for more detailed information. Drug Class and Mechanism PROMETRIUM is the only oral progesterone that is available in market. Missed Dose Despite your best attempts at remembering, if you still miss out on a dose, then take it as soon as you remember about it. But keep in mind that you will have to adjust your next dose by spacing it out by 4 to 5 hours. If this is not possible, then the best thing to do would be to skip the missed dose and continue with your normal dosage schedule. Never try to compensate for the missed dose by taking a double dose together. It may cause adverse effects. Storage Store PROMETRIUM at room temperature between 59 and 86 degrees F(15 and 30 degrees C). Always keep it in a cool dark place that is not directly exposed to sources of heat or moisture and sunlight. Protect it from kids and pets.