Drug Uses Trazodone is used for treating depression. It may also be used for relief of an anxiety disorder (e.g., sleeplessness, tension), chronic pain. It may also be used for other conditions as determined by your doctor. How to use Use Trazodone as directed by your doctor. Check the label on the medicine for exact dosing instructions. Trazodone comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Trazodone refilled. Take Trazodone shortly after a meal or light snack. It may take 1 to 4 weeks for Trazodone to work. Do not stop taking Trazodone without checking with your doctor. Drug Class and Mechanism Trazodone is a tetracyclic antidepressant. It is thought to increase the activity of one of the brain chemicals (serotonin), which helps elevate mood. Missed Dose If you miss a dose of Trazodone and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Storage Store Trazodone between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trazodone out of the reach of children and away from pets.